Significance of magnetic resonance imaging in evaluating perioperative chemotherapy and brain cognitive function in breast cancer patients
Magnetic resonance imaging in evaluating perioperative chemotherapy
AbstractObjective: The main objectives of this study were to evaluate the efficacy of magnetic resonance imaging (MRI) in affecting perioperative chemotherapy and brain cognitive function in women with breast cancer. Methods: 80 breast cancer chemotherapy patients were admitted to our hospital from March 2019 to February 2021 and were selected as the research objects. They were split into two groups based on the pathological efficacy assessment results, such as pathological remission and pathological non-remission. The differences in MRI parameters between the two groups were compared, and both groups underwent neuropsychology and haematology investigations. Results: Prior treatment, there were no statistically significant differences in lesion width, ADC value, NSE, or CEA between THE pCR group and the NON-PCR group (P>0.05). Post treatment, the lesion width, ADC value, NSE, and CEA in both groups were dramatically reduced when compared to pretreatment. THE pCR group's lesion diameter, NSE, and CEA were considerably lower than the NON-PCR group's, and the ADC value was significantly higher than the NON-PCR group's, with statistical significance (P<0.05). The ROC curve revealed that the ADC value had the highest sensitivity (89.21%) and the highest specificity (93.95%), both of which were lower than the parametric combination diagnosis (AUC = 0.915, sensitivity = 90.18%, specificity = 95.14%), and the variations were statistical significance (P<0.05). There were statistically significant variations in MMSE, MoCA, NCT-A, and DST scores among 80 patients prior and post treatment (P<0.05). Specifically, MMSE, MoCA, and DST scores of breast cancer patients after chemotherapy were considerably lower than before chemotherapy, although NCT-A scores were significantly higher. The difference was statistically significant (P<0.05). After chemotherapy, mfALFF values in the left posterior central gyrus, left inferior temporal gyrus, right middle temporal gyrus, and bilateral precuneus increased, whereas mfALFF values in the right caudate nucleus and left putamen reduced, with statistical variance (P<0.05). Conclusion: Magnetic resonance combined with serological indicators can effectively evaluate the effect of perioperative chemotherapy for breast cancer, and the application of resting state functional fMRI can also preliminarily evaluate the brain cognitive impairment of patients undergoing chemotherapy.
How to Cite
Huang, C. Z., Lin, C. K., Fu, Q. M., Huang, J. H., Jia, N., & Chen, Y. (2022). Significance of magnetic resonance imaging in evaluating perioperative chemotherapy and brain cognitive function in breast cancer patients: Magnetic resonance imaging in evaluating perioperative chemotherapy . The Ethiopian Journal of Health Development. Retrieved from https://ejhd.org/index.php/ejhd/article/view/4915