Clinical study of loratadine tablet combined with mometasone furoate nasal spray combined with acupoint application of traditional Chinese medicine in the treatment of allergic rhinitis
Application of traditional Chinese medicine in the treatment of allergic rhinitis
Abstract
Background: Allergic Rhinitis (AR) is a common variable of immune responses, affecting nearly 50 crores people worldwide. So, this study addresses both western and traditional Chinese medicinal practices to combine and mediate a potent result in treating AR patients.
Objective: To achieve a sustainable and long term impact of a treatment consisting of western medicines like synthetic corticosteroids and non-sedative antihistamine combined with the traditional Chinese medicine acupoint herbal patching on the Allergic Rhinitis patients.
Methods: Total 782 patients were included in this study. They were randomly divided into four groups maintaining approximately 1:1:1:1. The first group of patients were treated with Loratadine Tablet 10 mg and Mometasone furoate NS 200 microg (administered once in the morning at waking up and in empty stomach for 15 days) with placebo traditional Chinese medicine. While the second group of patients received the traditional Chinese medicine acupoint herbal patching with placebo tablets (Vitamin C, 100 mg). Now the third group was the integrated treatment group where the patients received both the treatments and the fourth group received only the placebos for both the treatment procedures.
Results: Different scales were employed to examine the different symptoms of AR, like, Visual Analog Scale (VAS), Total Nasal Symptom Score (TNSS), Total Symptom Score (TSS) etc. To measure the histological effects in response of the allergic reaction in AR in the patients, random blood testing was conducted. Statistical analysis was done in SPSS 17.0. Mean ± standard deviation (x–±s) was used to evaluate the continuous and normally distributed data. Geometric mean and standard deviation; ANOVA; Dunnett's test were done to determine any multiple comparisons if found. Then Chi square test was used for recapitulating data.
Conclusion: The study is a great success in achieving its result on the AR patients. But, to come with a definite sustainable result, the time period of the study is needed to be increased for at least a year, so that the effectiveness of this treatment on the changing seasons can be observed and thus statistically analysed.
