Effect of glucose management levels on the incidence of systemic inflammatory response syndrome (SIRS) in intensive care

Effect of glucose management levels of patients

Authors

  • Miaona Zheng
  • Guo Yu
  • Wanxian Lu
  • Miaohang Shan
  • Jingru Lan Department of Critical Medicine, The First Affiliated Hospital of Jinan University
  • Jiaying Li Department of Endocrinology, the First Affiliated Hospital of Jinan University
  • Peiru Zhou Physical examination center of the First Affiliated Hospital of Jinan University

Abstract

Objective: The regulation of glucose levels in ICU patients is intimately connected to the occurrence of SIRS.

Aim: To investigate the effect of glucose management level on the incidence of systemic inflammatory response syndrome (SIRS) in intensive care.

Methods: The study was carried out on 200 patients who were admitted to our hospital's intensive care unit (ICU) for treatment. According to their blood glucose control levels, they were separated into 3 groups. After 28 days following ICU admission, differences in serum inflammation level, blood glucose level, SIRS incidence, and death rate were compared.

Results: On the first day, there were no considerable variations in HR, RR, or T across the 3 groups. Only on the 7th day statistically significant variations  (P<0.05) were observed in group C. Group A's average blood glucose level was substantially reduced than groups B and C. Group A had much greater hypoglycemia than groups B and C. Insulin levels were substantially greater in groups A and B than in group C. Group A had a considerably reduced duration of stay and mechanical ventilation time than groups B and C. CRP, IL-6, TNF-, and insulin levels did not differ significantly between groups A and B. Group C had a considerably higher incidence of SIRS, MODS, and 28-day mortality. Group C had a high prevalence of nosocomial infection than groups A and B, while group B had a higher incidence than group A. The differences were statistically significant (P<0.05), and the logistic results showed that blood glucose levels and insulin dosage were risk factors for SIRS incidence (P0.05). Conclusion: Active control of blood glucose levels in ICU patients is beneficial to reduce the incidence of SIRS, according to the standard range.

Author Biographies

Miaona Zheng

Department of Critical Medicine, The First Affiliated Hospital of Jinan University

Guo Yu

School of nursing, Jinan University

Wanxian Lu

Department of Critical Medicine, The First Affiliated Hospital of Jinan University

Miaohang Shan

Department of Critical Medicine, The First Affiliated Hospital of Jinan University

Published

2022-09-26

How to Cite

Zheng, M., Yu, G., Lu, W., Shan, M. ., Lan, J., Li, J., & Zhou, P. (2022). Effect of glucose management levels on the incidence of systemic inflammatory response syndrome (SIRS) in intensive care: Effect of glucose management levels of patients. The Ethiopian Journal of Health Development. Retrieved from https://ejhd.org/index.php/ejhd/article/view/4556

Issue

Section

Original Articles

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