Antifertility effect of Jatropha Curcas L. seed in guinea pigs

Abstract

Abstract: A crude seed extract of Jatropha curcas was studied for its claimed anti-fertility effect. The extract was orally administered to matured female albino guinea pigs. It was found to reduce the number of births. This was further confirmed by the anti-implantation and abortifacient effects of the extract observed in this study. The extract was also found to prolong the oestrus cycle of guinea pigs. The diestrus phase was significantly increased, while the oestrus phase was shortened. The weight of the uterus was shown to reduce in animals treated with the extract, while that of the ovaries did not show a significant change from that of the control. These observations suggest that the seeds of the plant possess antifertility activity.[Ethiop. J. Health Dev. 1997;11(2):145-148]